Genotyping is the process of determining the genetic constitution – the genotype – of an individual by examining their DNA sequence. Looking at diversity between a species, disease-related mutations, or genetic characteristics associated with disease. We helps researchers to detect point mutations of interest, but also large structural changes in DNA. Genotyping is by far the most popular and effective way to screen samples for single nucleotide polymorphisms (SNPs). There are many applications for which genotyping technologies are useful.
Basic Genotyping Analysis Service
- Experimental data processing
- Data filtering (Hardy-Weinnberg equilibrium, missing genotypes)
- Genotype calling
Advanced Analysis of Genotyping services
- Statistical tests for association (using various models, eg: dominant / recessive) and sample clustering.
- Visualisation and determination of the Linkage Disequilibrium (LD) structure within the genotype data.
- Identify genes and gather all forms of annotation in the genomic regions of interest.
- Integrate genotype data with expression data to identify genomic regions regulating expression.
- Haplotype estimation and haplotype association analysis.
- Genomic structural variation identification, CNV and LOH analysis from SNP microarray data.
- Perform pathways network-based analyses of associated genes with Ariadne Pathway Studio.